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English: 3-Quinuclidinyl benzilate structure, ...

English: 3-Quinuclidinyl benzilate structure, animation  15x15px|Hydrogen|   15x15px|Carbon|   15x15px|Oxygen|   15x15px|Nitrogen|  (Photo credit: Wikipedia)

BZ Bombs Away

During the early 1960s Edgewood Arsenal, headquarters of the US Army Chemical Corps, received an average of four hundred chemical “rejects” every month from the maior American pharmaceutical firms. Rejects were drugs found to be commercially useless because of their undesirable side effects. Of course, undesirable side effects were precisely what the army was looking for.

It was from Hoffmann-La Roche in Nutley, New Jersey, that Edgewood Arsenal obtained its first sample of a drug called quinuclidinyl benzilate, or BZ for short. The army learned that BZ inhibits the production of a chemical substance that facilitates the transfer of messages along the nerve endings, thereby disrupting normal perceptual pattems. The effects generally lasted about three days, although symptoms–headaches, giddiness, disorientation, auditory and visual hallucinations, and maniacal behavior–could persist for as long as six weeks. “During the period of acute effects,” noted an army doctor, “the person is completely out of touch with his environment.”

Dr. Van Sim, who served as chief of the Clinical Research Division at Edgewood, made it a practice to try all new chemicals himself before testing them on volunteers. Sim said he sampled LSD “on several occasions.” Did he enjoy getting high, or were his acid trips simply a patriotic duty? “It’s not a matter of compulsiveness or wanting to be the first to try a material,” Sim stated. “With my experience I am often able to change the design of future experiments…. This allows more comprehensive tests to be conducted later, with maximum effective usefulness of inexperienced volunteers. I’m trying to defeat the compound, and if I can, we don’t have to drag out the tests at the expense of a lot of time and money.” With BZ, Dr. Sim seems to have met his match. “It zonked me for three days. I kept falling down and the people at the lab assigned someone to follow me around with a mattress. I woke up from it after three days without a bruise.” For his efforts Sim received the Decoration for Exceptional Civilian Service and was cited for exposing himself to dangerous drugs “at the risk of grave personal injury.”

According to Dr. Solomon Snyder, a leading psychopharmacologist at Johns Hopkins University, which conducted drug research for the Chemical Corps, “The army’s testing of LSD was just a sideshow compared to its use of BZ.” Clinical studies with EA-2277 (the code number for BZ) were initiated at Edgewood Arsenal in 1959 and continued until 1975.During this period an estimated twenty-eight hundred soldiers were exposed to the superhallucinogen. A number of military personnel have since come forward claiming that they were never the same after their encounter with BZ. Robert Bowen, a former air force enlisted man, felt disoriented for several weeks after his exposure. Bowen said the drug produced a temporary feeling of insanity but that he reacted less severely than other test subjects. One paratrooper lost all muscle control for a time and later seemed totally divorced from reality “The last time I saw him,” said Bowen, “he was taking a shower in his uniform and smoking a cigar.” During the early 1960s the CIA and the military began to phase out their in-house acid tests in favor of more powerful chemicals such as BZ, which became the army’s standard incapacitating agent. By this time the superhallucinogen was ready for deployment in a grenade, a 750-pound cluster bomb, and at least one other large-scale bomb. In addition the army tested a number of other advanced BZ munitions, including mortar, artillery, and missile warheads. The superhallucinogen was later employed by American troops as a counterinsurgency weapon in Vietnam, and according to CIA documents there may be contingency plans to use the drug in the event of a major civilian insurrection. As Major General William Creasy warned shortly after he retired from the Army Chemical Corps, “We will use these things as we very well see fit, when we think it is in the best interest of the US and their allies.”

3-Quinuclidinyl benzilate

 

3-Quinuclidinyl benzilate (QNBBZEA-2277), IUPAC name 1-azabicyclo[2.2.2]oct-3-yl 2-hydroxy-2,2-diphenylacetate, is an odorless military incapacitating agent.[1] ItsNATO code is BZ.

BZ is a glycolate anticholinergic compound related to atropinescopolamine,hyoscyamine, and other deliriants. Dispersal would be as an aerosolized solid (primarily for inhalation) or as agent dissolved in one or more solvents for ingestion or percutaneousabsorption.

Acting as a competitive inhibitor of acetylcholine at postsynaptic and postjunctionalmuscarinic receptor sites in smooth muscleexocrine glandsautonomic ganglia, and the brain, BZ decreases the effective concentration of acetylcholine seen by receptors at these sites. Thus, BZ causes PNS effects that in general are the opposite of those seen in nerve agent poisoning. CNS effects include stuporconfusion, and confabulation with concrete and panoramic illusions and hallucinations, and with regression to primitive, involuntary behaviors such as floccillation and disrobing.

Physostigmine, which increases the concentration of acetylcholine in synapses and inneuromuscular and neuroglandular junctions, is a specific antidote.

Production of BZ is controlled under schedule 2 of the Chemical Weapons Convention.

Background[edit]

Following World War II, the United States military investigated a wide range of possible nonlethal, psychoactive incapacitating agents including psychedelic drugs such as LSD and THCdissociative drugs such as ketamine and phencyclidine, potent opioids such asfentanyl, as well as several glycolate anticholinergics.[2][3]

History[edit]

One of the anticholinergic compounds, 3-quinuclidinyl benzilate, was assigned the NATO code BZ and was weaponized at the beginning of the 1960s for possible battlefield use. BZ was invented by Hoffman-LaRoche in 1951.[4] The company was investigating anti-spasmodic agents, similar to tropine, for treating gastrointestinal issues when the chemical was discovered.[4] In 1959 the United States Army began to show interest in using the chemical as a chemical warfare agent.[4] The agent was originally designated TK but when it was standardized by the U.S. Army in 1961 it was designated BZ.[4] The agent commonly became known as “Buzz” because of this abbreviation and the effects it had on the mental state of its casualties.[4]

Military use[edit]

The United States had weaponized BZ for delivery in the M44 generator cluster and the M43 cluster bomb until stocks were destroyed in 1989.